Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.52 |
| ▸ | PDE4A | P27815 | 13/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183553 | 0.87 | ADORA2B (0.57) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10184866 | 0.84 | ADORA2B (0.59) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL562533 | 0.83 | ADORA2B (0.58) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL562083 | 0.83 | PDE4A (0.55) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL562757 | 0.83 | ADORA2B (0.57) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL562019 | 0.82 | ADORA2B (0.54) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3913271 | 0.81 | ADORA2B (0.53) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL562941 | 0.81 | ADORA2B (0.63) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3911706 | 0.80 | ADORA2B (0.51) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL562432 | 0.79 | ADORA2B (0.59) | ADORA2BPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044074-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | Incyte Corporation (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007150025-A2 | PURINONE DERIVATIVES AS HM74A AGONISTS | INCYTE CORPORATION (US) | 2007-12-27 | — | — | WO | disclosed |