Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 6/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | BDKRB2 | P30411 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014463 | 0.92 | NR1H2 (0.43) | NR1H2NR1H3CYP4F2CYP4A11MAOB | |
| SCHEMBL4014198 | 0.90 | NR1H3 (0.47) | NR1H2NR1H3CYP4F2CYP4A11MAOB | |
| SCHEMBL4017788 | 0.85 | NR1H2 (0.59) | NR1H2NR1H3NR4A2 | |
| SCHEMBL3507547 | 0.82 | MEN1 (0.48) | NR1H2NR1H3CYP4F2CYP4A11MAOB | |
| SCHEMBL4012339 | 0.81 | NR1H2 (0.49) | NR1H2NR1H3CYP4F2CYP4A11MAOB | |
| SCHEMBL4012011 | 0.80 | NR1H3 (0.47) | NR1H2NR1H3CYP4F2CYP4A11 | |
| SCHEMBL4011836 | 0.79 | NR1H2 (0.48) | NR1H2NR1H3CYP4F2CYP4A11MAOB | |
| SCHEMBL4012832 | 0.77 | NR1H2 (0.57) | NR1H2NR1H3NR4A2 | |
| SCHEMBL4011445 | 0.77 | NR1H2 (0.59) | NR1H2NR1H3NR4A2 | |
| SCHEMBL4013824 | 0.77 | NR1H2 (0.56) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |