Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 20/20 | 0.71 |
| ▸ | MMP13 | P45452 | 19/20 | 0.71 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012444 | 1.00 | MMP12 (0.71) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4017660 | 0.87 | MMP12 (0.91) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL31490233 | 0.87 | MMP12 (0.91) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4012366 | 0.86 | MMP12 (0.77) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4012364 | 0.86 | MMP12 (0.77) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4008378 | 0.83 | MMP12 (1.00) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4010384 | 0.83 | MMP12 (0.63) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4010380 | 0.83 | MMP12 (0.63) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4010128 | 0.80 | MMP12 (0.73) | MMP12MMP13MMP2MMP3MMP9 | |
| SCHEMBL4010130 | 0.80 | MMP12 (0.73) | MMP12MMP13MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074107-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008057254-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH (US) | 2008-05-15 | — | — | WO | disclosed |