Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.39 |
| ▸ | CLK1 | P49759 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014357 | 0.83 | CSNK1E (0.42) | CLK1LMNAALDH1A1DYRK1AMEN1 | |
| SCHEMBL4018094 | 0.78 | CLK1 (0.64) | CLK1LMNAACHEALDH1A1DYRK1A | |
| SCHEMBL2170658 | 0.67 | DYRK1A (0.61) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14403544 | 0.63 | DYRK1A (0.71) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4012705 | 0.63 | CLK1 (0.61) | CLK1LMNAACHEALDH1A1DYRK1A | |
| SCHEMBL4012671 | 0.62 | CLK1 (0.74) | CLK1LMNAACHEALDH1A1DYRK1A | |
| SCHEMBL18166903 | 0.62 | CLK1 (0.74) | CLK1LMNAACHEALDH1A1DYRK1A | |
| SCHEMBL8035664 | 0.62 | CLK1 (0.56) | CLK1TP53LMNAALDH1A1DYRK1A | |
| SCHEMBL4170182 | 0.61 | CLK1 (0.58) | CLK1LMNAACHEALDH1A1DYRK1A | |
| SCHEMBL18363036 | 0.60 | HDAC1 (0.54) | HDAC1HDAC8HDAC6TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |