Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 3/20 | 0.42 |
| ▸ | CLK1 | P49759 | 3/20 | 0.42 |
| ▸ | CLK3 | P49761 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 3/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.40 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012474 | 0.83 | HDAC3 (0.39) | CLK1DYRK1AKMT2AMEN1ALDH1A1 | |
| SCHEMBL4012996 | 0.82 | NOX1 (0.40) | KMT2AMEN1MAPTLMNAPIM1 | |
| SCHEMBL2170658 | 0.82 | DYRK1A (0.61) | CSNK1ECLK1CLK3DYRK1ADYRK1B | |
| SCHEMBL4012671 | 0.75 | CLK1 (0.74) | CSNK1ECLK1CLK3DYRK1ADYRK1B | |
| SCHEMBL18166903 | 0.75 | CLK1 (0.74) | CSNK1ECLK1CLK3DYRK1ADYRK1B | |
| SCHEMBL4013844 | 0.71 | CSNK1E (0.38) | CSNK1ECLK1CLK3DYRK1ADYRK1B | |
| SCHEMBL31436172 | 0.70 | PIM1 (0.55) | MAPTALDH1A1LMNAHSD17B10PIM1 | |
| SCHEMBL15237156 | 0.64 | DRD2 (0.49) | KMT2AMAPTALDH1A1LMNAPIM1 | |
| SCHEMBL11593986 | 0.62 | MEN1 (0.52) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL4018094 | 0.62 | CLK1 (0.64) | CSNK1ECLK1CLK3DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |