Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | CLK1 | P49759 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.44 |
| ▸ | CLK3 | P49761 | 3/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.44 |
| ▸ | MAP3K19 | Q56UN5 | 2/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012680 | 1.00 | DYRK1A (0.47) | DYRK1AHTR2AHTR2CCLK1ALDH1A1 | |
| SCHEMBL8033618 | 0.88 | DYRK1A (0.46) | DYRK1AHTR2AHTR2CCLK1ALDH1A1 | |
| SCHEMBL4012795 | 0.87 | DYRK1A (0.61) | DYRK1AHTR2AHTR2CCLK1ALDH1A1 | |
| SCHEMBL4012802 | 0.87 | DYRK1A (0.61) | DYRK1AHTR2AHTR2CCLK1ALDH1A1 | |
| SCHEMBL4018492 | 0.83 | DYRK1A (0.62) | DYRK1AHTR2AHTR2CCLK1ALDH1A1 | |
| SCHEMBL4018499 | 0.83 | DYRK1A (0.62) | DYRK1AHTR2AHTR2CCLK1ALDH1A1 | |
| SCHEMBL4017421 | 0.82 | CLK1 (0.63) | DYRK1AHTR2AHTR2CCLK1ALDH1A1 | |
| SCHEMBL4017411 | 0.82 | CLK1 (0.63) | DYRK1AHTR2AHTR2CCLK1ALDH1A1 | |
| SCHEMBL4018422 | 0.79 | DYRK1A (0.46) | DYRK1AHTR2AHTR2CCLK1ALDH1A1 | |
| SCHEMBL4018427 | 0.79 | DYRK1A (0.46) | DYRK1AHTR2AHTR2CCLK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |