Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | CLK1 | P49759 | 8/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.45 |
| ▸ | CLK3 | P49761 | 3/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4018427 | 1.00 | DYRK1A (0.46) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL4012203 | 0.89 | DYRK1A (0.48) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL4012137 | 0.84 | DYRK1A (0.67) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL4012130 | 0.84 | DYRK1A (0.67) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL8033618 | 0.82 | DYRK1A (0.46) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL8032406 | 0.79 | DYRK1A (0.68) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL4012674 | 0.79 | DYRK1A (0.47) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL4012680 | 0.79 | DYRK1A (0.47) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL4018352 | 0.79 | DYRK1A (0.71) | DYRK1AHTR2AHTR2CCLK1CSNK1E | |
| SCHEMBL4018347 | 0.79 | DYRK1A (0.71) | DYRK1AHTR2AHTR2CCLK1CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |