Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 19/20 | 0.55 |
| ▸ | MMP13 | P45452 | 16/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012702 | 1.00 | MMP12 (0.55) | MMP12MMP13MMP1MMP2MMP3 | |
| SCHEMBL4010116 | 0.95 | MMP12 (0.53) | MMP12MMP13 | |
| SCHEMBL4010113 | 0.95 | MMP12 (0.53) | MMP12MMP13 | |
| SCHEMBL3072052 | 0.90 | MMP12 (0.59) | MMP12MMP13MMP1MMP2MMP3 | |
| SCHEMBL3072054 | 0.90 | MMP12 (0.59) | MMP12MMP13MMP1MMP2MMP3 | |
| SCHEMBL4011617 | 0.87 | MMP12 (0.73) | MMP12MMP13 | |
| SCHEMBL4011620 | 0.87 | MMP12 (0.73) | MMP12MMP13 | |
| SCHEMBL3085738 | 0.86 | MMP12 (0.74) | MMP12MMP13MMP1MMP2MMP3 | |
| SCHEMBL3080893 | 0.85 | MMP12 (0.59) | MMP12MMP13MMP1MMP2MMP3 | |
| SCHEMBL4014733 | 0.84 | MMP12 (0.53) | MMP12MMP13MMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074107-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008057254-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH (US) | 2008-05-15 | — | — | WO | disclosed |