Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 17/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | GRK5 | P34947 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4443019 | 0.95 | ATR (0.69) | ATRMAP4K4GRK5KDM4EALDH1A1 | |
| SCHEMBL4455054 | 0.88 | ATR (0.76) | ATRMAP4K4 | |
| SCHEMBL4450649 | 0.87 | ATR (0.68) | ATR | |
| SCHEMBL4014260 | 0.87 | ATR (0.68) | ATR | |
| SCHEMBL4163487 | 0.87 | ATR (0.68) | ATR | |
| SCHEMBL2481992 | 0.85 | ATR (1.00) | ATR | |
| SCHEMBL3063607 | 0.83 | ATR (1.00) | ATR | |
| SCHEMBL29458584 | 0.83 | ATR (1.00) | ATR | |
| SCHEMBL23153622 | 0.81 | ATR (0.78) | ATR | |
| SCHEMBL4010962 | 0.81 | ATR (0.68) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |