Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 2/20 | 0.42 |
| ▸ | ALPI | P09923 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3077820 | 0.93 | MEN1 (0.57) | KMT2AMEN1MAPTMAOAALPL | |
| SCHEMBL3085245 | 0.93 | MEN1 (0.61) | KMT2AMEN1MAPTMAOAALPL | |
| SCHEMBL7703302 | 0.85 | MEN1 (0.82) | KMT2AMEN1MAPTCYP11B1CYP11B2 | |
| SCHEMBL3065729 | 0.78 | MEN1 (0.61) | KMT2AMEN1MAPTMAOACA2 | |
| Dibenzofuran SCHEMBL28066911 | 0.77 | MEN1 (1.00) | KMT2AMEN1MAPTGAAPARP1 | |
| SCHEMBL483262 | 0.77 | MEN1 (1.00) | KMT2AMEN1MAPTGAAPARP1 | |
| SCHEMBL3072615 | 0.77 | TSHR (0.56) | KMT2AMEN1MAPTMAOAALPL | |
| SCHEMBL2990038 | 0.76 | MAPT (0.73) | KMT2AMEN1MAPTPARP1S100A4 | |
| SCHEMBL5332842 | 0.76 | MAPT (0.63) | KMT2AMEN1MAPTMAOAALPL | |
| SCHEMBL3085696 | 0.75 | HPGD (0.46) | KMT2AMEN1MAPTPKMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074107-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008057254-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH (US) | 2008-05-15 | — | — | WO | disclosed |