SCHEMBL483262

SCHEMBL483262

O=[N+]([O-])c1ccc2c(c1)oc1ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 1.00
KMT2A Q03164 6/20 1.00
MAPT P10636 5/20 1.00
TNKS O95271 1/20 0.55
PARP1 P09874 1/20 0.55
CSNK2A2 P19784 1/20 0.55
CSNK2B P67870 1/20 0.55
CSNK2A1 P68400 1/20 0.55
TNKS2 Q9H2K2 1/20 0.55
PARP2 Q9UGN5 1/20 0.55
AHR P35869 2/20 0.50
S100A4 P26447 1/20 0.49
ALDH1A1 P00352 3/20 0.49
KDM4E B2RXH2 2/20 0.49
HPGD P15428 1/20 0.49
NPC1 O15118 3/20 0.48
RAB9A P51151 3/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
NPSR1 Q6W5P4 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dibenzofuran SCHEMBL28066911 1.00 MEN1 (1.00) MEN1KMT2AMAPTTNKSPARP1
SCHEMBL9186989 0.92 MEN1 (0.84) MEN1KMT2AMAPTTNKSPARP1
SCHEMBL7703302 0.91 MEN1 (0.82) MEN1KMT2AMAPTS100A4ALDH1A1
SCHEMBL10810205 0.90 MEN1 (0.82) MEN1KMT2AMAPTTNKSPARP1
SCHEMBL2340821 0.89 MAPT (0.81) MEN1KMT2AMAPTTNKSPARP1
Dibenzofuran SCHEMBL27495466 0.89 MEN1 (0.79) MEN1KMT2AMAPTTNKSPARP1
SCHEMBL2990038 0.85 MAPT (0.73) MEN1KMT2AMAPTTNKSPARP1
SCHEMBL12113006 0.83 MAPT (0.71) MEN1KMT2AMAPTTNKSPARP1
SCHEMBL6524056 0.81 MAPT (0.69) MEN1KMT2AMAPTTNKSPARP1
SCHEMBL3072969 0.80 MEN1 (0.67) MEN1KMT2AMAPTGABRPGABRD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6362341-B1 ANTIINFLAMMATORY AGENTS ATHENA NEUROSCIENCES, INC. 2002-03-26 US claimed
EP-4701391-A2 HETEROLEPTIC IRIDIUM COMPLEX Universal Display Corporation (US) 2026-02-25 EP disclosed
US-12550604-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2026-02-10 US disclosed
EP-3643721-B1 HETEROLEPTIC IRIDIUM COMPLEX UNIVERSAL DISPLAY CORP (US) 2026-01-28 EP disclosed
US-20250268926-A1 METHOD AND COMPOSITION FOR TREATING, ALLEVIATING OR PREVENTING A DISEASE OR CONDITION CAUSED BY AIR POLLUTANT HONG KONG BAPTIST UNIVERSITY (CN) 2025-08-28 US disclosed
US-20240180020-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2024-05-30 US disclosed
US-20240092744-A1 TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF THE NATIONAL INSTITUTES OF PHARMACEUTICAL R&D CO., LTD (CN) 2024-03-21 US disclosed
US-11910701-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2024-02-20 US disclosed
EP-4273150-A1 TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF The National Institutes of Pharmaceutical R&D Co., Ltd (CN) 2023-11-08 EP disclosed
US-20230309376-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-09-28 US disclosed
US-6797710-B2 CARDIOVASCULAR DISORDERS; SERINE PROTEASE INHIBITOR; ADMINISTERING BY MOUTH; BIOAVAILABILITY AKZO NOBEL N.V. (NL) 2004-09-28 US disclosed
EP-1379239-A2 N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2004-01-14 EP disclosed
US-20030130270-A1 Heterocyclic derivatives and their use as antithrombotic agents MERCK SHARP & DOHME B.V. (NL) 2003-07-10 US disclosed
WO-2002078693-A2 N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2002-10-10 WO disclosed
US-6444672-B1 ORAL BIOVAILABILITY; INHIBITORS OF THROMBIN AND/OR FACTOR XA; SERINE PROTEASE INHIBITOR AKZO NOBEL N.V. (NL) 2002-09-03 US disclosed
US-6432955-B1 ANTICOAGULANTS AKZO NOBEL N.V. (NL) 2002-08-13 US disclosed
US-6194409-B1 SERINE PROTEASE INHIBITOR; BIOAVAILABILITY WHEN ADMINISTERED BY MOUTH AKZO NOBEL N.V. (NL) 2001-02-27 US disclosed
US-6037361-A GELATINASE, STROMELYSIN, COLLAGENASE, AND MATRILYSIN INHIBITORS; MULTIPLE SCLEROSIS TREATMENT; BRAIN AND NERVOUS SYSTEM DISORDERS WARNER-LAMBERT COMPANY (US) 2000-03-14 US disclosed
EP-0975600-A1 HETEROCYCLIC DERIVATIVES AND THEIR USE AS ANTITHROMBOTIC AGENTS Akzo Nobel N.V. (NL) 2000-02-02 EP disclosed
WO-1998047876-A1 HETEROCYCLIC DERIVATIVES AND THEIR USE AS ANTITHROMBOTIC AGENTS AKZO NOBEL N.V. (NL) 1998-10-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11910701-B2 Organic electroluminescent materials and devices ICOSLG, PDCD1LG2, NECTIN4 MEN1 2086/4885KMT2A 2568/4885MAPT 910/4885
US-20240180020-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES ICOSLG, PDCD1LG2, NECTIN4 MEN1 2086/4885KMT2A 2568/4885MAPT 910/4885
US-20240092744-A1 TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF GOT2, HADH, CYP4A11 MEN1 955/4885KMT2A 3581/4885MAPT 2211/4885
US-20230309376-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES ICOSLG, PDCD1LG2, NECTIN4 MEN1 2086/4885KMT2A 2568/4885MAPT 910/4885
US-12550604-B2 Organic electroluminescent materials and devices ROS1, DNMT3A, PRDM9 MEN1 1230/4885KMT2A 880/4885MAPT 1607/4885
US-20030130270-A1 Heterocyclic derivatives and their use as antithrombotic agents F2, F12, VKORC1 MEN1 1002/4885KMT2A 2507/4885MAPT 4873/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.