Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 6/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 2/20 | 0.35 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.35 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.35 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46676 | 0.95 | SLC34A2 (0.43) | SLC34A2BRAFHRH4SMYD2KDM4E | |
| SCHEMBL46466 | 0.93 | SLC34A2 (0.41) | SLC34A2BRAFHRH4SMYD2KDM4E | |
| SCHEMBL16804643 | 0.93 | BRAF (0.43) | SLC34A2BRAFHRH4KDM4ERAF1 | |
| SCHEMBL40137 | 0.93 | CHRM3 (0.43) | SLC34A2BRAFHRH4SMYD2KDM4E | |
| SCHEMBL46807 | 0.92 | SLC34A2 (0.41) | SLC34A2BRAFHRH4SMYD2KDM4E | |
| SCHEMBL39748 | 0.92 | SLC34A2 (0.41) | SLC34A2BRAFHRH4SMYD2KDM4E | |
| SCHEMBL40227 | 0.90 | SLC34A2 (0.41) | SLC34A2BRAFHRH4SMYD2KDM4E | |
| SCHEMBL10290803 | 0.90 | SLC34A2 (0.41) | SLC34A2BRAFHRH4SMYD2DRD2 | |
| SCHEMBL40112 | 0.88 | SLC34A2 (0.48) | SLC34A2BRAFHRH4SMYD2KDM4E | |
| SCHEMBL39897 | 0.87 | SLC34A2 (0.38) | SLC34A2BRAFHRH4SMYD2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |