Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.43 |
| ▸ | RAF1 | P04049 | 6/20 | 0.43 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46676 | 0.95 | SLC34A2 (0.43) | BRAFRAF1SLC34A2KDM1AHDAC1 | |
| SCHEMBL40137 | 0.93 | CHRM3 (0.43) | BRAFRAF1SLC34A2HRH4KDM4E | |
| SCHEMBL40133 | 0.93 | SLC34A2 (0.41) | BRAFRAF1SLC34A2KDM1AHDAC1 | |
| SCHEMBL46466 | 0.93 | SLC34A2 (0.41) | BRAFRAF1SLC34A2HRH4KDM4E | |
| SCHEMBL46807 | 0.92 | SLC34A2 (0.41) | BRAFRAF1SLC34A2HRH4KDM4E | |
| SCHEMBL10290802 | 0.91 | BRAF (0.42) | BRAFRAF1SLC34A2KDM1AHDAC1 | |
| SCHEMBL15432532 | 0.91 | SLC34A2 (0.43) | BRAFRAF1SLC34A2KDM1AHDAC1 | |
| SCHEMBL39748 | 0.90 | SLC34A2 (0.41) | BRAFSLC34A2HDAC1HRH4KDM4E | |
| SCHEMBL40227 | 0.89 | SLC34A2 (0.41) | BRAFRAF1SLC34A2HRH4KDM4E | |
| SCHEMBL10290803 | 0.89 | SLC34A2 (0.41) | BRAFSLC34A2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9301951-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-9301951-B2 | Compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20150164876-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. | 2015-06-18 | — | — | US | disclosed |
| US-20150164876-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. | 2015-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150164876-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | SLC34A2, SLC34A1, SLC10A2 | BRAF 3436/4885RAF1 3203/4885SLC34A2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.