Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 6/20 | 0.58 |
| ▸ | FYN | P06241 | 8/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.48 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008712 | 0.85 | FYN (0.51) | NEK2FYNPIK3CAALDH1A1GAA | |
| SCHEMBL11907493 | 0.83 | NEK2 (0.72) | NEK2FYN | |
| SCHEMBL23703221 | 0.81 | ATR (0.48) | NEK2PIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL11907360 | 0.80 | ATR (0.70) | NEK2CHEK1PRKDCATR | |
| SCHEMBL4011105 | 0.77 | MCHR1 (0.52) | NEK2ATR | |
| SCHEMBL11908281 | 0.77 | ATR (0.67) | PIK3CGPRKDCATR | |
| SCHEMBL3461060 | 0.77 | PIK3CD (0.67) | NEK2PIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL11909602 | 0.76 | MAP4K4 (0.50) | NEK2PRKDCATR | |
| SCHEMBL30048631 | 0.76 | ATR (0.67) | PRKDCATR | |
| SCHEMBL23703073 | 0.76 | ATR (0.67) | PRKDCATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |