Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.52 |
| ▸ | NEK2 | P51955 | 3/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3936085 | 0.81 | NEK2 (0.47) | NEK2MAP3K11ATR | |
| SCHEMBL4013350 | 0.77 | NEK2 (0.58) | NEK2ATR | |
| SCHEMBL220877 | 0.77 | NOS3 (0.61) | MCHR1ADORA2AADORA1LTA4HHRH3 | |
| SCHEMBL3928126 | 0.76 | MCHR1 (0.47) | MCHR1MAP3K11ADORA2AADORA1LTA4H | |
| SCHEMBL4008321 | 0.76 | ATR (0.55) | MCHR1MAP3K11ADORA2AADORA1ATR | |
| SCHEMBL15333931 | 0.76 | LTA4H (0.49) | MCHR1ADORA2AADORA1LTA4H | |
| SCHEMBL4006573 | 0.75 | ATR (0.59) | ATR | |
| SCHEMBL4012928 | 0.75 | ATR (0.54) | MCHR1CDK2MAP3K11ADORA2AADORA1 | |
| Hydrochloric Acid SCHEMBL7427266 | 0.74 | MCHR1 (0.53) | MCHR1ADORA2AADORA1HRH3 | |
| SCHEMBL15333915 | 0.74 | FYN (0.56) | MCHR1ADORA2AADORA1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |