Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.72 |
| ▸ | PGR | P06401 | 3/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.72 |
| ▸ | CNR1 | P21554 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.65 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | SHBG | P04278 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL349803 | 0.88 | ESR1 (0.78) | ESR1LMNANR3C1PGRCYP3A4 | |
| SCHEMBL17326003 | 0.88 | ESR1 (0.78) | ESR1LMNANR3C1PGRCYP3A4 | |
| SCHEMBL8931573 | 0.87 | ESR1 (0.74) | ESR1LMNANR3C1PGRCYP3A4 | |
| SCHEMBL19096138 | 0.87 | ESR1 (0.77) | ESR1LMNANR3C1PGRCYP3A4 | |
| SCHEMBL4395173 | 0.87 | ESR1 (0.77) | ESR1LMNANR3C1PGRCYP3A4 | |
| SCHEMBL19123270 | 0.87 | ESR1 (0.77) | ESR1LMNANR3C1PGRCYP3A4 | |
| SCHEMBL6872679 | 0.87 | ESR1 (0.77) | ESR1LMNANR3C1PGRCYP3A4 | |
| SCHEMBL17318121 | 0.87 | ESR1 (0.77) | ESR1LMNANR3C1PGRCYP3A4 | |
| SCHEMBL4389365 | 0.85 | ESR1 (0.77) | ESR1LMNANR3C1PGRCYP3A4 | |
| SCHEMBL457480 | 0.85 | ESR1 (0.74) | ESR1LMNANR3C1PGRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007396-A1 | NONSTEROIDAL PROGESTERONE RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-01-15 | — | — | WO | disclosed |