SCHEMBL457480

SCHEMBL457480

C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(OS(=O)(=O)C(C)C)ccc4[C@H]3CC[C@@]21C

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 5/20 0.74
LMNA P02545 3/20 0.74
NR3C1 P04150 3/20 0.74
PGR P06401 3/20 0.74
CYP3A4 P08684 3/20 0.74
SLC6A2 P23975 2/20 0.74
SLC6A4 P31645 2/20 0.74
SLC6A3 Q01959 2/20 0.74
CYP1A2 P05177 1/20 0.74
CYP2C19 P33261 1/20 0.74
HIF1A Q16665 1/20 0.74
CNR1 P21554 1/20 0.74
GAA P10253 1/20 0.69
MAPT P10636 1/20 0.69
MAPK1 P28482 1/20 0.69
ESR2 Q92731 2/20 0.67
ABCB11 O95342 2/20 0.67
SLC22A2 O15244 1/20 0.67
NR1I2 O75469 1/20 0.67
SHBG P04278 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL349803 0.90 ESR1 (0.78) ESR1LMNANR3C1PGRCYP3A4
SCHEMBL17326003 0.90 ESR1 (0.78) ESR1LMNANR3C1PGRCYP3A4
SCHEMBL17318121 0.89 ESR1 (0.77) ESR1LMNANR3C1PGRCYP3A4
SCHEMBL19123270 0.89 ESR1 (0.77) ESR1LMNANR3C1PGRCYP3A4
SCHEMBL4395173 0.89 ESR1 (0.77) ESR1LMNANR3C1PGRCYP3A4
SCHEMBL6872679 0.89 ESR1 (0.77) ESR1LMNANR3C1PGRCYP3A4
SCHEMBL19096138 0.89 ESR1 (0.77) ESR1LMNANR3C1PGRCYP3A4
SCHEMBL8505089 0.88 ESR1 (0.81) ESR1LMNANR3C1PGRCYP3A4
SCHEMBL4389365 0.87 ESR1 (0.77) ESR1LMNANR3C1PGRCYP3A4
SCHEMBL8931573 0.87 ESR1 (0.74) ESR1LMNANR3C1PGRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761252-A1 MATRIX-CONTROLLED TRANSDERMAL THERAPEUTIC SYSTEM BASED ON AN ADHESIVE FOR ADMINISTERING NORELGESTROMIN OR THE COMBINATION THEREOF WITH AN ESTROGEN HEXAL AG (DE) 2007-03-14 EP claimed
WO-2005120470-A1 MATRIX-CONTROLLED TRANSDERMAL THERAPEUTIC SYSTEM BASED ON AN ADHESIVE FOR ADMINISTERING NORELGESTROMIN OR THE COMBINATION THEREOF WITH AN ESTROGEN HEXAL AG (DE) 2005-12-22 WO claimed
US-20250188088-A1 COMPOUND AND USE THEREOF ONQUALITY PHARMACEUTICALS CHINA LTD. (CN) 2025-06-12 US disclosed
EP-4484429-A1 COMPOUND AND USE THEREOF OnQuality Pharmaceuticals China Ltd. (CN) 2025-01-01 EP disclosed
US-20230346820-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 THE SCRIPPS RESEARCH INSTITUTE 2023-11-02 US disclosed
US-20230346820-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 THE SCRIPPS RESEARCH INSTITUTE 2023-11-02 US disclosed
US-20200222352-A1 FORMULATIONS AND USES OF RETINOIC ACID RECEPTOR SELECTIVE AGONISTS QURETINO THERAPEUTICS, INC. 2020-07-16 US disclosed
US-20180133189-A1 FORMULATIONS AND USES OF RETINOIC ACID RECEPTOR SELECTIVE AGONISTS QURETINO THERAPEUTICS, INC. 2018-05-17 US disclosed
EP-2613772-B1 LOW-DOSE TRANSDERMAL PATCHES WITH HIGH DRUG RELEASE BAYER IP GMBH (DE) 2016-12-14 EP disclosed
US-20160038451-A1 FORMULATIONS AND USES OF RETINOIC ACID RECEPTOR SELECTIVE AGONISTS QURETINO THERAPEUTICS, INC. 2016-02-11 US disclosed
WO-2016005599-A1 COMPOSITIONS, METHODS AND USES FOR TREATING GENDER-BIASED IMMUNE DISORDERS BIOCOPEA LIMITED (GB) 2016-01-14 WO disclosed
EP-1054675-A1 REGULATION OF ESTRUS AND OVULATION IN GILTS Thorn Bioscience, LLC (US) 2000-11-29 EP disclosed
US-6028057-A INDUCING PSEUDOPREGNANCY IN FERTILE FEMALE PIGS COMPRISING ADMINISTERING TO THE PIGS AN EFFECTIVE AMOUNT OF A COMPOUND THAT INDUCES PSEUDOPREGNANCY IN A BIODEGRADABLE CONTROLLED RELEASE FORMULATION THORN BIOSCIENCE, LLC (US) 2000-02-22 US disclosed
US-6013276-A TREATING MENOPAUSE OR OSTEOPOROSIS USING A TRANSDERMAL MATRIX SYSTEM CONTAINING ETHYLENE-VINYL ACETATE COPOLYMER, 2-OCTADODECYL MYRISTATE, N(C4-C15)ALKYL-2-PYRROLIDONES AND ATLEAST ONE HORMONE SELECTED FROM PROGESTIN AND ESTROGEN LABORATORIES D'HYGIENE ET DE DIETETIQUE (FR) 2000-01-11 US disclosed
WO-1999042110-A1 REGULATION OF ESTRUS AND OVULATION IN GILTS THORN BIOSCIENCE, LLC (US) 1999-08-26 WO disclosed
US-5605702-A Eva-based transdermal matrix system for the administration of an estrogen and/or a progestogen LABORATOIRES D'HYGIENE ET DE DIETETIQUE (FR) 1997-02-25 US disclosed
US-5580572-A FOR PERCUTANEOUS ADMINISTRATION OF HORMONES LABORATOIRES D'HYGIENE ET DE DIETETIQUE (FR) 1996-12-03 US disclosed
US-5128124-A Administration of norethistereone-17-acetate CIBA-GEIGY CORPORATION (US) 1992-07-07 US disclosed
US-4913905-A PATCH CONTAINING ESTROGEN, SYNTHETIC GESTAGEN, ALKANOL TO ENHANCE PERCUTANEOUS ABSORPTION CIBA-GEIGY CORPORATION (US) 1990-04-03 US disclosed
EP-0285563-A1 Transdermal therapeutic systems for combinations of active agents CIBA-GEIGY AG (CH) 1988-10-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180133189-A1 FORMULATIONS AND USES OF RETINOIC ACID RECEPTOR SELECTIVE AGONISTS RARA, RARB, RARG ESR1 254/4885LMNA 1683/4885NR3C1 281/4885
US-20200222352-A1 FORMULATIONS AND USES OF RETINOIC ACID RECEPTOR SELECTIVE AGONISTS RARA, RARB, RARG ESR1 254/4885LMNA 1683/4885NR3C1 281/4885
US-20160038451-A1 FORMULATIONS AND USES OF RETINOIC ACID RECEPTOR SELECTIVE AGONISTS RARA, RARB, RARG ESR1 254/4885LMNA 1683/4885NR3C1 281/4885
US-20230346820-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 ACE2, SARS1, ACE ESR1 3467/4885LMNA 2675/4885NR3C1 921/4885
US-20250188088-A1 COMPOUND AND USE THEREOF CYP17A1, CYP11B2, CYP21A2 ESR1 3792/4885LMNA 1711/4885NR3C1 1716/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.