Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | XDH | P47989 | 4/20 | 0.39 |
| ▸ | CDC7 | O00311 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL384224 | 0.82 | CDC7 (0.54) | IDO1PIM1XDHCDC7KDM4E | |
| SCHEMBL3340046 | 0.81 | IDO1 (0.47) | IDO1PIM1XDHCDC7KDM4E | |
| SCHEMBL13305003 | 0.81 | CDC7 (0.52) | IDO1PIM1XDHCDC7GSK3B | |
| SCHEMBL384910 | 0.80 | PIM1 (0.65) | IDO1PIM1XDHCDC7KDM4E | |
| SCHEMBL4019927 | 0.79 | PIM1 (0.59) | PIM1CDC7KDM4EGSK3BCSNK2A1 | |
| SCHEMBL383352 | 0.78 | PIM1 (0.51) | IDO1PIM1XDHCDC7KDM4E | |
| SCHEMBL3345673 | 0.73 | CDC7 (0.46) | IDO1PIM1CDC7KDM4EGSK3B | |
| SCHEMBL14023022 | 0.72 | PIM1 (0.55) | PIM1XDHCDC7KDM4EGSK3B | |
| SCHEMBL385518 | 0.71 | PIM1 (0.67) | PIM1XDHCDC7KDM4EGSK3B | |
| SCHEMBL386224 | 0.71 | PIM1 (0.67) | PIM1XDHCDC7KDM4EGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074114-A1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008143759-A1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |