Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.59 |
| ▸ | CDC7 | O00311 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27823252 | 0.80 | PIM1 (0.63) | PIM1CDC7KDM4EHPGDHSD17B10 | |
| SCHEMBL4013502 | 0.79 | IDO1 (0.47) | PIM1CDC7KDM4EHPGDHSD17B10 | |
| SCHEMBL3339712 | 0.76 | PIM1 (0.64) | PIM1CDC7KDM4EHPGDHSD17B10 | |
| SCHEMBL386562 | 0.74 | PIM1 (1.00) | PIM1CDC7KDM4EHPGDHSD17B10 | |
| SCHEMBL3327759 | 0.74 | PIM1 (0.58) | PIM1CDC7KDM4EHPGDHSD17B10 | |
| SCHEMBL3332894 | 0.73 | PIM1 (0.59) | PIM1CDC7KDM4EHPGDHSD17B10 | |
| SCHEMBL28793366 | 0.72 | PIM1 (0.53) | PIM1CDC7KDM4EHPGDHSD17B10 | |
| SCHEMBL3330003 | 0.69 | PIM1 (0.54) | PIM1CDC7KDM4EHPGDHSD17B10 | |
| SCHEMBL7453928 | 0.68 | MAOA (0.49) | CDC7KDM4EHPGDALDH1A1GSK3B | |
| SCHEMBL383190 | 0.66 | PIM1 (0.83) | PIM1CDC7KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074114-A1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008143759-A1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |