Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 10/20 | 0.62 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.62 |
| ▸ | RXRA | P19793 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 9/20 | 0.53 |
| ▸ | CA1 | P00915 | 9/20 | 0.53 |
| ▸ | CA2 | P00918 | 9/20 | 0.53 |
| ▸ | CA9 | Q16790 | 9/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013387 | 0.90 | NR1H2 (0.69) | NR1H2NR1H3RXRACA12CA1 | |
| SCHEMBL4011929 | 0.88 | NR1H2 (0.70) | NR1H2NR1H3RXRACA12CA1 | |
| SCHEMBL4010900 | 0.88 | NR1H2 (0.62) | NR1H2NR1H3RXRACA12CA1 | |
| SCHEMBL4013268 | 0.82 | NR1H2 (0.81) | NR1H2NR1H3RXRACA12CA1 | |
| SCHEMBL4013147 | 0.81 | NR1H2 (0.63) | NR1H2NR1H3 | |
| SCHEMBL27786968 | 0.78 | NR1H2 (0.56) | NR1H2NR1H3RXRAPPARG | |
| SCHEMBL4012330 | 0.77 | NR1H2 (0.76) | NR1H2NR1H3RXRA | |
| SCHEMBL4012168 | 0.77 | NR1H2 (1.00) | NR1H2NR1H3RXRA | |
| SCHEMBL4013652 | 0.76 | NR1H2 (0.95) | NR1H2NR1H3RXRA | |
| SCHEMBL4013120 | 0.76 | NR1H2 (0.77) | NR1H2NR1H3RXRAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | claimed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | disclosed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |