Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 19/20 | 0.72 |
| ▸ | NR1H3 | Q13133 | 18/20 | 0.72 |
| ▸ | RXRA | P19793 | 1/20 | 0.72 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012797 | 0.91 | NR1H3 (0.77) | NR1H2NR1H3RXRA | |
| SCHEMBL4012467 | 0.87 | NR1H2 (0.86) | NR1H2NR1H3RXRA | |
| SCHEMBL1125243 | 0.84 | NR1H2 (0.69) | NR1H2NR1H3RXRAPDE4APDE4B | |
| SCHEMBL1125227 | 0.84 | NR1H2 (0.66) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL4017135 | 0.84 | NR1H2 (1.00) | NR1H2NR1H3RXRA | |
| SCHEMBL4012032 | 0.83 | NR1H2 (0.85) | NR1H2NR1H3RXRA | |
| SCHEMBL1125271 | 0.83 | NR1H2 (0.56) | NR1H2NR1H3RXRAPDE4APDE4B | |
| SCHEMBL1125070 | 0.83 | NR1H2 (0.57) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125144 | 0.83 | NR1H2 (0.57) | NR1H2NR1H3RXRAPPARGPPARD | |
| SCHEMBL1125391 | 0.83 | NR1H2 (0.66) | NR1H2NR1H3RXRAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |