Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MST1R | Q04912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397663 | 0.89 | MET (0.52) | METKCNH2MST1R | |
| SCHEMBL2447227 | 0.76 | MET (0.77) | METKCNH2MST1R | |
| SCHEMBL4389280 | 0.74 | MET (0.52) | METKCNH2MST1R | |
| SCHEMBL2329079 | 0.72 | MET (1.00) | METKCNH2 | |
| SCHEMBL399405 | 0.72 | MET (0.65) | METMST1R | |
| SCHEMBL2325953 | 0.70 | MET (0.56) | METKCNH2MST1R | |
| SCHEMBL10176091 | 0.70 | MET (0.52) | METKCNH2MST1R | |
| SCHEMBL2446414 | 0.70 | MET (0.73) | METKCNH2 | |
| SCHEMBL2330091 | 0.70 | MET (0.59) | METKCNH2 | |
| SCHEMBL2446446 | 0.69 | MET (0.70) | METKCNH2MST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101603-B2 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-01-24 | — | — | US | disclosed |