Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891635 | 0.89 | PPARG (0.50) | PPARGALDH1A1GAAMAPK1GSK3B | |
| SCHEMBL4012577 | 0.87 | PPARG (0.57) | PPARGAGTR1AGTR2ACHE | |
| SCHEMBL4016898 | 0.86 | PPARG (0.54) | PPARGAGTR1ACHE | |
| SCHEMBL4009893 | 0.85 | PPARG (0.51) | PPARGAGTR1AGTR2 | |
| SCHEMBL4007590 | 0.85 | PPARG (0.53) | PPARGAGTR1ACHE | |
| SCHEMBL4016260 | 0.80 | PPARG (0.52) | PPARGAGTR1ACHE | |
| SCHEMBL4306420 | 0.80 | PPARG (0.52) | PPARGAGTR1AGTR2ACHE | |
| SCHEMBL4011616 | 0.79 | PPARG (0.51) | PPARGAGTR1AGTR2ACHE | |
| SCHEMBL4012893 | 0.79 | PPARG (0.51) | PPARGAGTR1AGTR2ACHE | |
| SCHEMBL4016128 | 0.78 | PPARG (0.60) | PPARGAGTR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074117-A2 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008062905-A2 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-29 | — | — | WO | disclosed |