Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 15/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL721831 | 0.76 | MEN1 (0.36) | MAP3K11 | |
| SCHEMBL30799999 | 0.72 | MAP3K11 (0.45) | MAP3K11GSK3B | |
| SCHEMBL30615391 | 0.72 | ALDH1A1 (0.61) | MAP3K11 | |
| SCHEMBL723157 | 0.71 | MAP3K11 (1.00) | MAP3K11LRRK2 | |
| SCHEMBL722100 | 0.71 | MAP3K11 (0.43) | MAP3K11GSK3B | |
| SCHEMBL23926962 | 0.71 | MAP3K11 (0.45) | MAP3K11LRRK2 | |
| SCHEMBL30079230 | 0.71 | MAP3K11 (0.45) | MAP3K11LRRK2 | |
| SCHEMBL722624 | 0.70 | MAP3K11 (1.00) | MAP3K11LRRK2 | |
| SCHEMBL34462992 | 0.70 | GSK3B (0.42) | MAP3K11GSK3B | |
| SCHEMBL720512 | 0.70 | MAP3K11 (1.00) | MAP3K11LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796467-A4 | IMIDAZO{4,5-B}PYRAZINONE INHIBITORS OF PROTEIN KINASES | JANSSEN PHARMACEUTICA NV (BE) | 2009-07-01 | — | — | EP | disclosed |
| EP-1796467-A2 | IMIDAZO{4,5-B}PYRAZINONE INHIBITORS OF PROTEIN KINASES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006036883-A2 | IMIDAZO{4,5-B}PYRAZINONE INHIBITORS OF PROTEIN KINASES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-04-06 | — | — | WO | disclosed |