Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011931 | 0.94 | KDM4E (0.46) | KDM4EPTGDR2ALDH1A1KMT2AMEN1 | |
| SCHEMBL4017920 | 0.82 | PKM (0.44) | KDM4EALDH1A1KMT2AMAPTPKM | |
| SCHEMBL4010336 | 0.78 | KDM4E (0.41) | KDM4EPTGDR2ALDH1A1KMT2AMEN1 | |
| SCHEMBL4013174 | 0.76 | PTGDR2 (0.43) | KDM4EPTGDR2ALDH1A1KMT2AMEN1 | |
| SCHEMBL29140059 | 0.75 | KDM4E (0.65) | KDM4EALDH1A1KMT2AMEN1PKM | |
| SCHEMBL14366676 | 0.74 | GAA (0.37) | ALDH1A1KMT2AMAPTGAA | |
| SCHEMBL3929084 | 0.73 | MAPT (0.55) | KDM4EPTGDR2ALDH1A1KMT2AMEN1 | |
| SCHEMBL3938045 | 0.73 | MAPT (0.55) | KDM4EPTGDR2ALDH1A1KMT2AMEN1 | |
| SCHEMBL3941517 | 0.73 | MAPT (0.55) | KDM4EPTGDR2ALDH1A1KMT2AMEN1 | |
| SCHEMBL3942010 | 0.72 | USP5 (0.61) | PTGDR2KMT2APKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |