Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.50 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013403 | 0.85 | GBA1 (0.51) | HRH4AKT1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1623325 | 0.81 | AKT1 (0.48) | HRH4AKT1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1623322 | 0.81 | AKT1 (0.48) | HRH4AKT1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4016152 | 0.81 | HRH4 (0.44) | HRH4ALDH1A1RAD52 | |
| SCHEMBL5503906 | 0.79 | HRH4 (0.51) | HRH4SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL3718191 | 0.79 | SMN1; SMN2 (0.62) | HRH4SMN1; SMN2MEN1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL4020304 | 0.78 | HRH4 (0.50) | HRH4SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL22631353 | 0.78 | ABL1 (0.45) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL5503125 | 0.77 | HRH4 (0.52) | HRH4SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL183884 | 0.77 | PRKDC (0.47) | HRH4AKT1ALDH1A1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784393-B1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2006028904-A9 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2006-06-22 | — | — | WO | disclosed |