Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | PRKDC | P78527 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL183884 | 0.93 | PRKDC (0.47) | HRH4OPRK1PRKDCRAD52KDM4E | |
| SCHEMBL4019288 | 0.87 | CNR1 (0.46) | OPRK1 | |
| SCHEMBL4012962 | 0.85 | KDM4E (0.46) | OPRK1PRKDCKDM4EALDH1A1HPGD | |
| SCHEMBL4012954 | 0.85 | KDM4E (0.46) | OPRK1PRKDCKDM4EALDH1A1HPGD | |
| SCHEMBL4013931 | 0.81 | HRH4 (0.50) | HRH4RAD52ALDH1A1 | |
| SCHEMBL183991 | 0.81 | PDE10A (0.47) | PRKDC | |
| SCHEMBL183992 | 0.81 | PDE10A (0.47) | PRKDC | |
| SCHEMBL5503125 | 0.81 | HRH4 (0.52) | HRH4PAK1ALDH1A1 | |
| SCHEMBL1623785 | 0.80 | SMAD3 (0.54) | EGLN1KDM4EALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL4012898 | 0.80 | HRH4 (0.51) | HRH4PAK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784393-B1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2009-07-01 | — | — | EP | disclosed |