Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 4/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.43 |
| ▸ | CLK1 | P49759 | 5/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.43 |
| ▸ | CLK3 | P49761 | 3/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.43 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LGMN | Q99538 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4167871 | 0.89 | DYRK1A (0.45) | DYRK1ACLK1CSNK1ECLK3DYRK1B | |
| SCHEMBL8022482 | 0.88 | DYRK1A (0.44) | DYRK1ACLK1CSNK1ECLK3DYRK1B | |
| SCHEMBL4017395 | 0.85 | CLK1 (0.63) | PRKDCDYRK1ACLK1CSNK1ECLK3 | |
| SCHEMBL8035664 | 0.80 | CLK1 (0.56) | DYRK1ACLK1CSNK1ECLK3DYRK1B | |
| SCHEMBL8029984 | 0.78 | CLK1 (0.68) | DYRK1ACLK1CSNK1ECLK3DYRK1B | |
| SCHEMBL8031570 | 0.77 | CLK1 (0.69) | DYRK1ACLK1CSNK1ECLK3DYRK1B | |
| SCHEMBL4016943 | 0.75 | DYRK1A (0.49) | DYRK1ACLK1CSNK1ECLK3DYRK1B | |
| SCHEMBL14299605 | 0.74 | KMT2A (0.47) | MEN1KMT2AALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL4013673 | 0.73 | CLK1 (0.67) | DYRK1ACLK1CSNK1ECLK3DYRK1B | |
| SCHEMBL4014110 | 0.73 | DYRK1A (0.52) | DYRK1ACLK1CSNK1ECLK3DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |