Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.52 |
| ▸ | CLK1 | P49759 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.47 |
| ▸ | CLK3 | P49761 | 3/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.47 |
| ▸ | CLK2 | P49760 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.47 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013603 | 0.86 | MAPT (0.47) | DYRK1ACLK1MAPTALDH1A1HPGD | |
| SCHEMBL8022002 | 0.82 | MAPT (0.46) | DYRK1ACLK1MAPTALDH1A1HPGD | |
| SCHEMBL9357971 | 0.82 | ALDH1A1 (0.71) | DYRK1ACLK1MAPTALDH1A1HPGD | |
| SCHEMBL9357967 | 0.82 | ALDH1A1 (0.71) | DYRK1ACLK1MAPTALDH1A1HPGD | |
| SCHEMBL8032406 | 0.81 | DYRK1A (0.68) | DYRK1ACLK1MAPTALDH1A1HPGD | |
| SCHEMBL27908255 | 0.80 | MAPT (0.54) | MAPTALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL24718936 | 0.80 | DYRK1A (0.49) | DYRK1ACLK1MAPTALDH1A1HPGD | |
| SCHEMBL4154294 | 0.80 | DYRK1A (0.49) | DYRK1ACLK1MAPTALDH1A1HPGD | |
| SCHEMBL4016943 | 0.80 | DYRK1A (0.49) | DYRK1ACLK1MAPTALDH1A1HPGD | |
| SCHEMBL27908259 | 0.80 | MAPT (0.45) | MAPTALDH1A1HPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009085226-A2 | INHIBITORS OF CDC2-LIKE KINASES (CLKS) AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |