Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.74 |
| ▸ | CSF1R | P07333 | 3/20 | 0.74 |
| ▸ | KIT | P10721 | 3/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.70 |
| ▸ | KDR | P35968 | 3/20 | 0.70 |
| ▸ | LCK | P06239 | 4/20 | 0.59 |
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.55 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932944 | 0.95 | BRAF (0.82) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL28197245 | 0.90 | CYP11B2 (0.67) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3944484 | 0.89 | CSF1R (0.73) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3939789 | 0.87 | BRAF (0.75) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3943780 | 0.86 | BRAF (0.73) | BRAFCSF1RCYP11B1CYP11B2 | |
| SCHEMBL1276318 | 0.85 | BRAF (1.00) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3937125 | 0.84 | CSF1R (0.79) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL2948209 | 0.84 | BTK (0.76) | CSF1RMAPK14KDRLCKSRC | |
| SCHEMBL1276797 | 0.84 | BRAF (0.78) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3932792 | 0.84 | BRAF (0.80) | BRAFCSF1RKITMAPK14KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |