Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 14/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132330 | 0.82 | CHEK1 (0.68) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL4016551 | 0.82 | CHEK1 (0.70) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL4017264 | 0.82 | CHEK1 (0.70) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL4016550 | 0.82 | CHEK1 (0.70) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL5130032 | 0.80 | CHEK1 (0.68) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL5129531 | 0.80 | CHEK1 (0.53) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL5123971 | 0.80 | CHEK1 (0.57) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL14192070 | 0.78 | CHEK1 (0.52) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL5125899 | 0.78 | CHEK1 (0.55) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL5123881 | 0.75 | CHEK1 (0.55) | CHEK1KCNH2AURKAKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550477-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-06-23 | — | — | US | claimed |
| US-20090023767-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-01-22 | — | — | US | claimed |
| EP-1976523-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-10-08 | — | — | EP | claimed |
| WO-2007081572-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-07-19 | — | — | WO | claimed |
| US-7550477-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550477-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550477-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-20090023767-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-01-22 | — | — | US | disclosed |
| US-20090023767-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-01-22 | — | — | US | disclosed |
| US-20090023767-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-01-22 | — | — | US | disclosed |
| EP-1976523-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007081572-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-07-19 | — | — | WO | disclosed |
| WO-2007081572-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023767-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, BUB1B | CHEK1 1/4885KCNH2 2921/4885AURKA 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.