Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.64 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.53 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.48 |
| ▸ | TUBB | P07437 | 2/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL414815 | 0.88 | AXL (0.64) | AXLAAK1PAK1CYP2C9CYP2D6 | |
| SCHEMBL411163 | 0.87 | AAK1 (0.56) | AXLAAK1PAK1CYP2C9CYP2D6 | |
| SCHEMBL855582 | 0.86 | AAK1 (0.57) | AXLAAK1PAK1CYP2C9CYP2D6 | |
| SCHEMBL4014801 | 0.86 | AXL (0.60) | AXLAAK1PAK1CYP2C9CYP2D6 | |
| SCHEMBL857781 | 0.86 | AAK1 (0.50) | AXLAAK1PAK1TUBB4ATUBB | |
| SCHEMBL855729 | 0.85 | AAK1 (0.56) | AXLAAK1PAK1CYP2C9CYP2D6 | |
| SCHEMBL412694 | 0.85 | AAK1 (0.56) | AXLAAK1PAK1CYP2C9CYP2D6 | |
| SCHEMBL409659 | 0.85 | AAK1 (0.56) | AXLAAK1PAK1CYP2C9CYP2D6 | |
| SCHEMBL412193 | 0.85 | KIT (0.55) | AXLAAK1PAK1CYP2C9CYP2D6 | |
| SCHEMBL414875 | 0.84 | AAK1 (0.55) | AXLAAK1PAK1CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504509-B2 | Compounds and methods for development of Ret modulators | PLEXXIKON, INC. (US) | 2009-03-17 | — | — | US | claimed |