Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.60 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856967 | 0.87 | AXL (0.59) | AXLAAK1CDK8CYP2C9PAK1 | |
| SCHEMBL4014735 | 0.86 | AXL (0.64) | AXLAAK1CDK8CYP2C9PDGFRB | |
| SCHEMBL857953 | 0.86 | AXL (0.64) | AXLAAK1CDK8CYP2C9PDGFRB | |
| SCHEMBL416109 | 0.85 | CYP2C9 (0.52) | AXLAAK1CYP2C9CYP3A4PAK1 | |
| SCHEMBL856681 | 0.84 | CDK8 (0.46) | AXLAAK1CDK8CYP2C9CYP3A4 | |
| SCHEMBL20086209 | 0.83 | AXL (0.60) | AXLAAK1CDK8PAK1CCNT1 | |
| SCHEMBL414606 | 0.83 | NEK1 (0.50) | AXLAAK1CYP2C9CYP3A4PAK1 | |
| SCHEMBL415917 | 0.83 | KIT (0.55) | AXLCYP2C9 | |
| SCHEMBL857546 | 0.83 | AXL (0.62) | AXLAAK1CDK8PDGFRBPDGFRA | |
| SCHEMBL411642 | 0.82 | AXL (0.59) | AXLAAK1CDK8CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504509-B2 | Compounds and methods for development of Ret modulators | PLEXXIKON, INC. (US) | 2009-03-17 | — | — | US | claimed |