Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 13/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016957 | 0.88 | KDM4E (0.44) | CCR1HSD17B10MEN1KMT2AKDM4E | |
| SCHEMBL4019904 | 0.85 | CCR1 (0.53) | CCR1LMNA | |
| SCHEMBL4019925 | 0.83 | CCR1 (0.40) | CCR1LMNA | |
| SCHEMBL4018625 | 0.83 | CCR1 (0.53) | CCR1MEN1KMT2A | |
| SCHEMBL4309602 | 0.83 | CCR1 (0.39) | CCR1 | |
| SCHEMBL4018084 | 0.82 | LMNA (0.42) | CCR1HSD17B10MEN1KMT2AKDM4E | |
| SCHEMBL4022376 | 0.82 | CCR1 (0.54) | CCR1MEN1KMT2A | |
| SCHEMBL4016533 | 0.81 | CCR1 (0.39) | CCR1MEN1KMT2ALMNA | |
| SCHEMBL4014637 | 0.81 | CCR1 (0.41) | CCR1 | |
| SCHEMBL4013644 | 0.81 | CCR1 (0.48) | CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |