Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 18/20 | 0.72 |
| ▸ | PRKDC | P78527 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008289 | 0.99 | ATR (0.73) | ATRPRKDCATMEGFRKDM4E | |
| SCHEMBL2483748 | 0.89 | ATR (0.71) | ATRPRKDCATM | |
| SCHEMBL2513033 | 0.84 | ATR (1.00) | ATRPRKDCATM | |
| SCHEMBL28160890 | 0.83 | KMT2A (0.57) | KDM4EALDH1A1MAPTTSHRMAPK1 | |
| SCHEMBL4016014 | 0.82 | ATR (0.66) | ATRPRKDCATMEGFR | |
| SCHEMBL4013295 | 0.82 | ATR (0.57) | ATRPRKDCATM | |
| SCHEMBL4009204 | 0.81 | ATR (0.67) | ATRPRKDCATMEGFR | |
| SCHEMBL4564500 | 0.79 | ATR (0.64) | ATRPRKDCATMEGFR | |
| SCHEMBL4041720 | 0.77 | ATR (0.82) | ATRPRKDCATMEGFR | |
| SCHEMBL4006264 | 0.77 | ATR (0.69) | ATRPRKDCATMEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |