Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 16/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL281339 | 0.91 | SCN9A (0.51) | SCN9A | |
| SCHEMBL484060 | 0.86 | SCN9A (0.51) | SCN9A | |
| SCHEMBL280904 | 0.84 | SCN9A (0.63) | SCN9A | |
| SCHEMBL281985 | 0.83 | SCN9A (0.62) | SCN9A | |
| SCHEMBL280703 | 0.83 | SCN9A (0.66) | SCN9A | |
| SCHEMBL281190 | 0.81 | SCN9A (0.66) | SCN9A | |
| SCHEMBL280823 | 0.79 | SCN9A (0.65) | SCN9A | |
| SCHEMBL281214 | 0.79 | SCN9A (0.74) | SCN9AALDH1A1 | |
| SCHEMBL281892 | 0.79 | SCN9A (0.66) | SCN9A | |
| SCHEMBL280730 | 0.79 | SCN9A (0.66) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2073806-A2 | USE OF SPIRO-OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008060789-A2 | USE OF SPIRO-OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-05-22 | — | — | WO | disclosed |