Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.57 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13769755 | 0.90 | PDE10A (0.59) | PDE10AGPR119HTR1ASLC6A2SLC6A4 | |
| SCHEMBL13769613 | 0.88 | PDE10A (0.59) | PDE10AGPR119HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4009125 | 0.87 | PDE10A (0.56) | PDE10AGPR119HTR1ASLC6A2SLC6A4 | |
| SCHEMBL13770041 | 0.87 | HTR1A (0.58) | PDE10AGPR119HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4007303 | 0.86 | HTR1A (0.49) | PDE10AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12712674 | 0.86 | CHRM4 (0.54) | GPR119GAATHRBSMN1; SMN2CHRM4 | |
| SCHEMBL4009229 | 0.85 | PDE10A (0.68) | PDE10AGPR119HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4010245 | 0.85 | HTR1A (0.61) | PDE10AGPR119HTR1ASLC6A2SLC6A4 | |
| SCHEMBL13769767 | 0.85 | PDE10A (0.58) | PDE10AGPR119JAK2JAK3PTK2 | |
| SCHEMBL4009199 | 0.84 | PDE10A (0.51) | PDE10AGPR119HTR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |