SCHEMBL401558

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL403796	0.83	PDE5A (0.64)	KDM4ERECQLPDE5APOLBTDP1
	SCHEMBL404328	0.82	PDE5A (0.60)	KDM4ERECQLPDE5APOLBTDP1
	SCHEMBL401317	0.82	PDE5A (0.62)	KDM4ERECQLPDE5APOLBTDP1
	SCHEMBL400774	0.82	PDE5A (0.62)	KDM4ERECQLPDE5APOLBTDP1
	SCHEMBL405782	0.81	POLB (0.59)	KDM4ERECQLPDE5APOLBTDP1
	SCHEMBL402561	0.79	KDM4E (0.66)	KDM4ERECQLPDE5APOLBALDH1A1
	SCHEMBL404827	0.78	PDE5A (0.58)	KDM4ERECQLPDE5APOLBTDP1
	SCHEMBL405344	0.78	PDE5A (0.63)	KDM4ERECQLPDE5APOLBTDP1
	SCHEMBL403999	0.78	PDE5A (0.63)	KDM4ERECQLPDE5APOLBALDH1A1
	SCHEMBL405463	0.78	KDM4E (0.58)	KDM4ERECQLPDE5ATDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.