SCHEMBL403796

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL401317	0.93	PDE5A (0.62)	PDE5AKDM4ERECQLPOLBRNASEH1
	SCHEMBL403588	0.92	PDE5A (0.53)	PDE5AKDM4ERECQLPOLBRNASEH1
	SCHEMBL405344	0.91	PDE5A (0.63)	PDE5AKDM4ERECQLPOLBRNASEH1
	SCHEMBL405463	0.90	KDM4E (0.58)	PDE5AKDM4ERECQLALDH1A1HPGD
	SCHEMBL404601	0.90	KDM4E (0.56)	PDE5AKDM4ERECQLPOLBRNASEH1
	SCHEMBL405899	0.89	KDM4E (0.56)	PDE5AKDM4ERECQLALDH1A1HPGD
	SCHEMBL403999	0.87	PDE5A (0.63)	PDE5AKDM4ERECQLPOLBALDH1A1
	SCHEMBL13368151	0.85	POLB (0.57)	KDM4EPOLBRNASEH1ALDH1A1HPGD
	SCHEMBL17888980	0.85	POLB (0.50)	PDE5AKDM4EPOLBRNASEH1ALDH1A1
	SCHEMBL404142	0.84	PDE5A (0.69)	PDE5AKDM4ERECQLPOLBRNASEH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.