Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.43 |
| ▸ | FPR3 | P25089 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016421 | 1.00 | KDM4E (0.57) | KDM4EPKMKMT2AEPHX1NPC1 | |
| SCHEMBL19652088 | 0.88 | KDM4E (0.60) | KDM4EPKMKMT2AEPHX1NPC1 | |
| SCHEMBL21176252 | 0.88 | KDM4E (0.53) | KDM4EPKMKMT2AEPHX1NPC1 | |
| SCHEMBL21176375 | 0.85 | KDM4E (0.50) | KDM4EPKMKMT2AEPHX1NPC1 | |
| SCHEMBL21176196 | 0.81 | KDM4E (0.47) | KDM4EPKMKMT2AEPHX1NPC1 | |
| SCHEMBL21176301 | 0.81 | KDM4E (0.48) | KDM4EPKMKMT2AEPHX1GPR119 | |
| SCHEMBL24853346 | 0.81 | KDM4E (0.64) | KDM4EPKMEPHX1FPR3FPR2 | |
| SCHEMBL1245476 | 0.81 | KDM4E (0.64) | KDM4EPKMEPHX1GPR119FPR3 | |
| SCHEMBL6152939 | 0.81 | KDM4E (0.68) | KDM4EPKMEPHX1GPR119FPR3 | |
| SCHEMBL28767036 | 0.81 | EPHX2 (0.40) | KDM4EPKMKMT2AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784393-B1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2009-07-01 | — | — | EP | disclosed |