Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15896797 | 0.81 | IDO1 (0.36) | IDO1GRM5TLR8 | |
| SCHEMBL3459509 | 0.75 | IDO1 (0.51) | IDO1GRM5 | |
| SCHEMBL4019007 | 0.72 | TNKS2 (0.46) | GRM5 | |
| SCHEMBL1398812 | 0.69 | MAPT (0.45) | KMT2AALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL4016456 | 0.69 | IDO1 (0.39) | IDO1GRM5 | |
| SCHEMBL275781 | 0.68 | GRM5 (0.43) | IDO1GRM5KMT2AALDH1A1POLB | |
| SCHEMBL11319174 | 0.66 | MAPT (0.36) | KMT2AMEN1NPC1RAB9A | |
| SCHEMBL18400687 | 0.65 | IDO1 (0.44) | IDO1TLR8 | |
| SCHEMBL275779 | 0.65 | GRM5 (0.43) | GRM5KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL8807969 | 0.62 | IDO1 (0.43) | IDO1GRM5KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009087220-A1 | USE OF THIAZOLOIMIDAZOLES, THIAZOLOTETRAZOLES AND THIAZOLOTRIAZOLES AS MGLUR5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | claimed |
| WO-2009087220-A1 | USE OF THIAZOLOIMIDAZOLES, THIAZOLOTETRAZOLES AND THIAZOLOTRIAZOLES AS MGLUR5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |