Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 18/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 17/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 17/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 15/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4016458 | 0.72 | IDO1 (0.39) | GRM5 | |
| SCHEMBL4019004 | 0.70 | TNKS2 (0.42) | TNKS2PARP2PARP15PARP10PARP14 | |
| SCHEMBL4014392 | 0.69 | TNKS2 (0.44) | TNKS2PARP2PARP15PARP10PARP14 | |
| SCHEMBL11319174 | 0.65 | MAPT (0.36) | — | |
| Tricyclazole SCHEMBL14721539 | 0.60 | BRPF1 (1.00) | TNKS2PARP2PARP15PARP10PARP14 | |
| SCHEMBL673415 | 0.60 | TNKS2 (1.00) | TNKS2PARP2PARP15PARP10PARP14 | |
| SCHEMBL13018164 | 0.58 | TNKS2 (0.38) | TNKS2PARP2PARP15PARP10PARP14 | |
| SCHEMBL13458868 | 0.57 | BRD4 (0.42) | TNKS2PARP2PARP15PARP10BRPF1 | |
| SCHEMBL15896797 | 0.57 | IDO1 (0.36) | GRM5 | |
| SCHEMBL4402257 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009087220-A1 | USE OF THIAZOLOIMIDAZOLES, THIAZOLOTETRAZOLES AND THIAZOLOTRIAZOLES AS MGLUR5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | claimed |
| WO-2009087220-A1 | USE OF THIAZOLOIMIDAZOLES, THIAZOLOTETRAZOLES AND THIAZOLOTRIAZOLES AS MGLUR5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | disclosed |