Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 7/20 | 0.65 |
| ▸ | SUV39H1 | O43463 | 2/20 | 0.54 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.54 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | STK4 | Q13043 | 1/20 | 0.43 |
| ▸ | STK3 | Q13188 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.42 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4024568 | 0.95 | PAK1 (0.68) | PAK1SUV39H1PRMT1SMYD3CYP1A2 | |
| SCHEMBL4581895 | 0.88 | PAK1 (0.68) | PAK1CYP1A2CYP2D6P2RX7MEN1 | |
| SCHEMBL4024856 | 0.88 | PAK1 (0.67) | PAK1SUV39H1PRMT1SMYD3CYP1A2 | |
| SCHEMBL4557267 | 0.87 | ALDH1A1 (0.54) | PAK1P2RX7MEN1KMT2A | |
| SCHEMBL4025750 | 0.86 | PAK1 (0.66) | PAK1SUV39H1PRMT1SMYD3CYP1A2 | |
| SCHEMBL4020785 | 0.86 | PAK1 (0.66) | PAK1SUV39H1PRMT1SMYD3CYP1A2 | |
| SCHEMBL4024042 | 0.85 | PAK1 (0.71) | PAK1P2RX7MEN1KMT2ACNR1 | |
| SCHEMBL4016410 | 0.85 | PAK1 (0.64) | PAK1SUV39H1PRMT1SMYD3CYP1A2 | |
| SCHEMBL4017800 | 0.84 | PAK1 (0.55) | PAK1SUV39H1PRMT1SMYD3CYP1A2 | |
| SCHEMBL4016414 | 0.84 | PAK1 (0.63) | PAK1SUV39H1PRMT1SMYD3P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066654-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | Bayer Schering Pharma AG (DE) | 2009-06-10 | — | — | EP | claimed |
| WO-2008028691-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | claimed |