SCHEMBL4016505

SCHEMBL4016505

CCNC(=O)Nc1ccc2c(c1)sc1cc(S(=O)(=O)N[C@H](C(=O)O)C(C)C)ccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MMP12 P39900 20/20 1.00
MMP13 P45452 16/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4011972 0.89 MMP12 (1.00) MMP12MMP13
SCHEMBL31490241 0.88 MMP12 (1.00) MMP12MMP13
SCHEMBL4012630 0.88 MMP12 (1.00) MMP12MMP13
SCHEMBL31490276 0.88 MMP12 (1.00) MMP12MMP13
SCHEMBL4010311 0.88 MMP12 (1.00) MMP12MMP13
SCHEMBL4011224 0.87 MMP12 (0.83) MMP12MMP13
SCHEMBL31490343 0.87 MMP12 (0.83) MMP12MMP13
SCHEMBL4010016 0.87 MMP12 (0.86) MMP12MMP13
SCHEMBL31490350 0.87 MMP12 (0.86) MMP12MMP13
SCHEMBL4009978 0.86 MMP12 (0.85) MMP12MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2074107-A2 TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS Wyeth a Corporation of the State of Delaware (US) 2009-07-01 EP claimed
WO-2008057254-A2 TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS WYETH (US) 2008-05-15 WO claimed
WO-2025056602-A1 PHARMACEUTICAL COMPOSITIONS AND USE THEREOF IN TREATMENT OF CONDITIONS AND DISEASES RELATED TO ELASTIN DEFICIENCY AND/OR AGING Elastin Biosciences Ltd. (GB) 2025-03-20 WO disclosed
EP-2074107-A2 TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS Wyeth a Corporation of the State of Delaware (US) 2009-07-01 EP disclosed
WO-2008057254-A2 TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS WYETH (US) 2008-05-15 WO disclosed
WO-2008057254-A2 TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS WYETH (US) 2008-05-15 WO disclosed