Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 11/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 11/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017280 | 0.93 | NR1H2 (0.58) | NR1H2NR1H3RXRALRRK2PTGDR2 | |
| SCHEMBL4015112 | 0.90 | NR1H2 (0.62) | NR1H2NR1H3RXRALRRK2GCK | |
| SCHEMBL4012434 | 0.88 | NR1H2 (0.52) | NR1H2NR1H3RXRALRRK2PTGDR2 | |
| SCHEMBL4016986 | 0.87 | NR1H2 (0.56) | NR1H2NR1H3RXRALRRK2PTGDR2 | |
| SCHEMBL4011793 | 0.85 | NR1H2 (0.72) | NR1H2NR1H3RXRA | |
| SCHEMBL4016991 | 0.84 | NR1H3 (0.59) | NR1H2NR1H3RXRAPTGDR2GCK | |
| SCHEMBL4009726 | 0.83 | NR1H2 (0.73) | NR1H2NR1H3RXRA | |
| SCHEMBL4017312 | 0.82 | NR1H2 (0.71) | NR1H2NR1H3RXRALRRK2PTGDR2 | |
| SCHEMBL4013990 | 0.82 | NR1H2 (0.52) | NR1H2NR1H3RXRAFFAR1PTGDR2 | |
| SCHEMBL4017885 | 0.81 | NR1H2 (0.52) | NR1H2NR1H3RXRAPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |