Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 6/20 | 0.50 |
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | HTR7 | P34969 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 3/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3556337 | 0.91 | HTR2A (0.49) | HTR2AHTR2CHTR1ADRD2HTR7 | |
| SCHEMBL3941201 | 0.88 | TSHR (0.48) | HTR2AHTR2CHTR1ADRD2HTR7 | |
| SCHEMBL3568841 | 0.86 | HTR2A (0.53) | HTR2AHTR2CDRD2HTR7ALDH1A1 | |
| SCHEMBL3942876 | 0.77 | HTR2A (0.51) | HTR2AHTR2CDRD2HTR7ALDH1A1 | |
| SCHEMBL3553137 | 0.77 | SLC6A2 (0.55) | HTR2AHTR2CALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3557281 | 0.74 | NAMPT (0.47) | HTR2AALDH1A1ALOX15MEN1KMT2A | |
| SCHEMBL3555264 | 0.74 | NAMPT (0.47) | HTR2AHTR1ADRD2HTR7ALDH1A1 | |
| SCHEMBL3560035 | 0.71 | NAMPT (0.44) | HTR2AALDH1A1ALOX15MEN1KMT2A | |
| SCHEMBL4883738 | 0.70 | MEN1 (0.50) | HTR2AHTR2CMEN1KMT2A | |
| SCHEMBL20379633 | 0.69 | NPSR1 (0.66) | ALDH1A1GAATSHRSMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1856305-B | Pyridine derivatives as urotensin II antagonists | ACTELION PHARMACEUTICALS LTD | 2010-04-28 | — | — | CN | disclosed |
| EP-1670470-B1 | PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-04-08 | — | — | EP | disclosed |
| CN-1856305-A | Pyridine derivatives and their use as urotensin II antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2006-11-01 | — | — | CN | disclosed |