Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 8/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.36 |
| ▸ | SIK1 | P57059 | 1/20 | 0.35 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29953748 | 0.75 | LRRK2 (0.57) | LRRK2ROCK2CDC7MAP4K4PRKACA | |
| SCHEMBL28613800 | 0.74 | GRM5 (0.49) | GRM5KMT2A | |
| SCHEMBL856933 | 0.72 | LRRK2 (0.47) | LRRK2ROCK2CDC7MAP4K4PIM1 | |
| SCHEMBL1364100 | 0.71 | AXL (0.45) | LRRK2CDC7MAP4K4CLK4JAK2 | |
| SCHEMBL29952435 | 0.71 | LRRK2 (0.51) | LRRK2ROCK2CDC7MAP4K4PIM1 | |
| SCHEMBL857462 | 0.71 | LRRK2 (0.43) | LRRK2ROCK2CDC7MAP4K4PIM1 | |
| SCHEMBL857898 | 0.71 | LRRK2 (0.41) | LRRK2JAK2AXL | |
| SCHEMBL3623201 | 0.70 | JAK2 (0.46) | LRRK2ROCK2CDC7MAP4K4PIM1 | |
| SCHEMBL856857 | 0.70 | LRRK2 (0.40) | LRRK2ROCK2CDC7MAP4K4PIM1 | |
| SCHEMBL27888107 | 0.70 | KMT2A (0.67) | ROCK2CDC7MAP4K4PIM1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504509-B2 | Compounds and methods for development of Ret modulators | PLEXXIKON, INC. (US) | 2009-03-17 | — | — | US | claimed |