Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.71 |
| ▸ | PPARG | P37231 | 2/20 | 0.57 |
| ▸ | PPARD | Q03181 | 2/20 | 0.57 |
| ▸ | PPARA | Q07869 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | HTR1F | P30939 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2086144 | 0.86 | HTR6 (0.71) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL4021090 | 0.85 | HTR6 (0.55) | HTR6HTR1ADRD2DRD3HTR1D | |
| SCHEMBL4018793 | 0.85 | HTR6 (0.69) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL3621334 | 0.85 | HTR6 (0.69) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL3611707 | 0.84 | HTR6 (0.67) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL17927580 | 0.83 | HTR6 (1.00) | HTR6FABP4HTR1ADRD2DRD3 | |
| SCHEMBL30406347 | 0.83 | HTR6 (1.00) | HTR6FABP4HTR1ADRD2DRD3 | |
| SCHEMBL23144154 | 0.82 | HTR6 (0.64) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL3621509 | 0.82 | HTR6 (0.64) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL3607517 | 0.81 | HTR6 (0.63) | HTR6POLBL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046741-B1 | INDOLES AS 5-HT6 MODULATORS | PROXIMAGEN LTD (GB) | 2012-10-31 | — | — | EP | claimed |
| EP-2046741-B1 | INDOLES AS 5-HT6 MODULATORS | PROXIMAGEN LTD (GB) | 2012-10-31 | — | — | EP | disclosed |
| EP-2046741-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (publ) (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003703-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2008-01-10 | — | — | WO | disclosed |