Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL780792 | 0.91 | NAMPT (0.42) | CHRNA7TP53SMN1; SMN2 | |
| SCHEMBL780239 | 0.86 | CHRNA7 (0.57) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| Hydrochloric Acid SCHEMBL780952 | 0.85 | CHRNA7 (0.57) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| SCHEMBL3940090 | 0.78 | CHRNA7 (0.47) | CHRNA7CHRNB2CHRNA4KCNH2CHRNA1 | |
| SCHEMBL3926764 | 0.77 | CHRNA7 (0.66) | CHRNA7CHRNB2CHRNA4KCNH2CHRNA1 | |
| SCHEMBL779905 | 0.76 | GPR119 (0.44) | CHRNA7CHRNB2CHRNA4KCNH2CHRNA1 | |
| SCHEMBL3939380 | 0.71 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4CHRNA1CHRNB1 | |
| SCHEMBL780438 | 0.70 | CHRNA7 (0.47) | CHRNA7GAACHRNB2CHRNA4KCNH2 | |
| SCHEMBL3930902 | 0.69 | NPSR1 (0.48) | CHRNA7CHRNB2CHRNA4CHRNA1CHRNB1 | |
| SCHEMBL15841980 | 0.68 | CHRNA7 (0.58) | CHRNA7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044038-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | Cornerstone Therapeutics Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146066-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | CRITICAL THERAPEUTICS, INC. (US) | 2007-12-21 | — | — | WO | disclosed |