Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.45 |
| ▸ | SUV39H2 | Q9H5I1 | 10/20 | 0.43 |
| ▸ | USP14 | P54578 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL183991 | 0.94 | PDE10A (0.47) | CKS1BSKP1SKP2SUV39H2PDE10A | |
| SCHEMBL183992 | 0.94 | PDE10A (0.47) | CKS1BSKP1SKP2SUV39H2PDE10A | |
| SCHEMBL4016152 | 0.87 | HRH4 (0.44) | OPRK1 | |
| SCHEMBL1622192 | 0.83 | CNR1 (0.46) | CNR1CNR2CKS1BSKP1SKP2 | |
| SCHEMBL2603709 | 0.82 | PRKDC (0.42) | CNR2OPRK1SUV39H2PDE10A | |
| SCHEMBL4013403 | 0.81 | GBA1 (0.51) | CNR1CNR2CKS1BSKP1SKP2 | |
| SCHEMBL30377235 | 0.81 | PDE10A (0.56) | CNR1CNR2CKS1BSKP1SKP2 | |
| SCHEMBL17628044 | 0.81 | PDE10A (0.56) | CNR1CNR2CKS1BSKP1SKP2 | |
| SCHEMBL17628041 | 0.81 | PDE10A (0.56) | CNR1CNR2CKS1BSKP1SKP2 | |
| SCHEMBL29648048 | 0.81 | PDE10A (0.44) | SUV39H2PDE10ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784393-B1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1784393-B1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2009-07-01 | — | — | EP | disclosed |